The intestinal epithelial stem cell: the mucosal governor

The intestinal epithelial stem cell: the mucosal governor.

All epithelial cells in the small and large intestine are thought to originate from stem cells located towards the base of the crypts of Lieberkühn. To-date, there are no specific intestinal stem cell markers, hence stem cell properties can only be inferred. A range of experimental techniques have been employed including cell position mapping, radiation regeneration (clonogenic) assays, chimeri...

Intestinal Epithelial Antigen Induces Mucosal

Intestinal autoimmune diseases are thought to be associated with a breakdown in tolerance, leading to mucosal lymphocyte activation perhaps as a result of encounter with bacterium-derived Ag. To study mucosal CD8 ؉ T cell activation, tolerance, and polarization of autoimmune reactivity to self-Ag, we developed a novel (Fabpl 4؋ at ؊132-OVA) transgenic mouse model expressing a truncated form of ...

The intestinal epithelial cell.

1 SHOULD first like to thank you for inviting me to be the Robert Campbell Orator on this occasion. For anyone in the field of medical science it is a great honour to give this lecture, for a Queen's graduate it is a very special honour, but for a Queen's graduate who is also an exile, it is not only an honour but a very welcome opportunity to come back again to this medical school. Although my...

A Mucosal Intranet: Intestinal Epithelial Cells

Mesenchymal Stem Cells Trigger Epithelial to Mesenchymal Transition in the HT-29 Colorectal Cancer Cell Line

Background and Objective: Mesenchymal stem cells (MSCs) promote metastasis in colorectal cancer; however, the mechanism underlying this process is not fully understood. Epithelial to mesenchymal transition (EMT) is a key step in tumor acquisition of metastatic phenotype. We aimed to investigate the effect of MSCs on the expression of EMT markers, as well as cancer stem cell markers in HT-29 col...